一、个人简历

马志永，博士，研究员，博士生导师，团队首席科学家。现任中国农科院上海兽医研究所所长、党委副书记，上海市畜牧兽医学会理事长。

长期从事乙型脑炎等人畜共患病和猪呼吸道传染病研究，探究宿主先天性抗病毒反应机制及病毒逃逸机制，寻找抗病毒药物设计的靶标分子，研发新型诊断技术和疫苗。主持国家级和省部级项目课题20余项。在《PLoS Pathogens》《Journal of Virology》《Journal of Biological Chemistry》等国内外杂志上发表论文150余篇，其中SCI论文100余篇，获专利16余项。

二、联系方式

邮      箱：zhiyongma@shvri.ac.cn

三、代表论著

1. Ma X, Li C, Xia Q, Zhang Y, Yang Y, Wahaab A, Liu K, Li Z, Li B, Qiu Y, Wei J, Ma Z. Construction of a Recombinant Japanese Encephalitis Virus with a Hemagglutinin-Tagged NS2A: A Model for an Analysis of Biological Characteristics and Functions of NS2A during Viral Infection. Viruses. 2022 Mar 29;14(4):706. doi: 10.3390/v14040706. PMID: 35458436; PMCID: PMC9024733.

2. Hameed M, Wahaab A, Nawaz M, Khan S, Nazir J, Liu K, Wei J, Ma Z. Potential Role of Birds in Japanese Encephalitis Virus Zoonotic Transmission and Genotype Shift. Viruses. 2021 Feb 24;13(3):357. doi: 10.3390/v13030357. PMID: 33668224; PMCID: PMC7996159.

3. Wang X, Wu Z, Li Y, Yang Y, Xiao C, Liu X, Xiang X, Wei J, Shao D, Liu K, Deng X, Wu J, Qiu Y, Li B, Ma Z. p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication. PLoS Pathog. 2020 Oct 27;16(10):e1009035. doi: 10.1371/journal.ppat.1009035. Epub ahead of print. PMID: 33108395.

4. Li C, Di D, Huang H, Wang X, Xia Q, Ma X, Liu K, Li B, Shao D, Qiu Y, Li Z, Wei J, Ma Z. NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings. PLoS Pathog. 2020 Sep 3;16(9):e1008773. doi: 10.1371/journal.ppat.1008773. PMID: 32881988; PMCID: PMC7494076.

5. Liu K, Xiao C, Xi S, Hameed M, Wahaab A, Shao D, Li Z, Li B, Wei J, Qiu Y, Miao D, Zhu H, Ma Z. Mosquito Defensins Enhance Japanese Encephalitis Virus Infection by Facilitating Virus Adsorption and Entry within the Mosquito. J Virol. 2020 Oct 14;94(21):e01164-20. doi: 10.1128/JVI.01164-20.

6. Wei J, Hameed M, Wang X, Zhang J, Guo S, Anwar MN, Pang L, Liu K, Li B, Shao D, Qiu Y, Zhong D, Zhou B, Ma Z. Antiviral activity of phage display-selected peptides against Japanese encephalitis virus infection in vitro and in vivo. Antiviral Res. 2020 Feb;174:104673. doi: 10.1016/j.antiviral.2019.104673. Epub 2019 Dec 5. PMID: 31812636.

7. Anwar MN, Wang X, Hameed M, Wahaab A, Li C, Sharma M, Pang L, Malik MI, Liu K, Li B, Qiu Y, Wei J, Ma Z. Phenotypic and Genotypic Comparison of a Live-Attenuated Genotype I Japanese Encephalitis Virus SD12-F120 Strain with Its Virulent Parental SD12 Strain. Viruses. 2020 May 16;12(5):552. doi: 10.3390/v12050552. PMID: 32429445; PMCID: PMC7290960.

8. Hameed M, Khan S, Xu J, Zhang J, Wang X, Di, Chen Z, Anwar MN, Wahaab A, Ma X, Nawaz M, Liu K, Li B, Shao D, Qiu Y, Wei J, Ma Z. Detection of Japanese Encephalitis Virus in Mosquitoes from Xinjiang during Next Generation Sequencing Arboviral Surveillance. Transbound Emerg Dis. 2020 Jul 2. doi: 10.1111/tbed.13697. Epub ahead of print. PMID: 32614516.

9. Hameed M, Liu K, Anwar MN, Wahaab A, Safdar A, Di D, Boruah P, Xu J, Wang X, Li B, Zhu H, Nawaz M, Shao D, Qiu Y, Wei J, Ma Z. The emerged genotype I of Japanese encephalitis virus shows an infectivity similar to genotype III in Culex pipiens mosquitoes from China. PLoS Negl Trop Dis. 2019 Sep 26;13(9):e0007716. doi: 10.1371/journal.pntd.0007716. eCollection 2019 Sep.

10. Wei J, Wang X, Zhang J, Guo S, Pang L, Shi K, Liu K, Shao D, Qiu Y, Liu L, Widén F, Li B, Ma Z. Partial cross-protection between Japanese encephalitis virus genotype I and III in mice. PLoS Negl Trop Dis. 2019 Aug 2;13(8):e0007601. doi: 10.1371/journal.pntd.0007601. eCollection 2019 Aug.

四、代表专利标准

1、一种重组载体及其在制备或筛选抗流感药物中的应用，授权时间：2025-08-06，发明专利号：ZL201610141142.9

2、一种重组载体及其在制备或筛选抗流感药物中的应用，授权时间：2025-08-06，发明专利号：ZL201610139667.9

3、抑制流感病毒相关基因的siRNA及其应用，授权时间：2025-08-06，发明专利号：ZL201210019712.9

4、抑制流感病毒复制的宿主相关基因及其筛选方法和应用，授权时间：2025-08-06，发明专利号：ZL201210019736.4

5、抑制流感病毒相关基因的siRNA及其应用，授权时间：2018-8-31，发明专利号：ZL201610139670.0

6、一类抗乙型脑炎病毒感染的组合物及其应用，授权时间：2025-08-06，发明专利号：ZL201510391532.7

7、一类N-(2-噻唑)苯甲酰胺衍生物的应用，授权时间：2013-9-11，发明专利号：ZL201010237252.8

8、一步法检测Z/S亚型埃博拉病毒的实时荧光定量PCR方法及其试剂盒，授权时间：2017-3-22，发明专利号：ZL201110312855.4

9、一种检测埃博拉病毒的荧光定量PCR检测方法及其引物和试剂盒，授权时间：2016-6-8，发明专利号：ZL201110312915.2

10、一种鉴定梅山猪或其肉制品的专用引物、方法和试剂盒，授权时间：2016-8-24，发明专利号：ZL201510088708.1